Prof. Yvon Julé, Biocellvia’s Chief Scientific Officer, co-signed a scientific publication with a prestigious research team from Belgium : the team directed by Prof. Isabelle Leclercq from University of Louvain in Laboratory Investigation. This article is entitled : “Automated computerized image analysis for the user-independent evaluation of disease severity in preclinical models of NAFLD/NASH“.
This publication demonstrates robustness and reliability of data produced by Biocellvia softwares. The abstract of the article concludes with these words : “The automated procedure also faithfully captured and quantitated macrovesicular steatosis, mixed inflammation, and pericellular fibrosis in CDAA-induced steatohepatitis. In conclusion, the automatic numerical analysis represents a promising quantitative method to rapidly monitor NAFLD activity with high-throughput in large preclinical studies and for accurate monitoring of disease evolution.”
This article is a strong reference for Biocellvia’s technology that evaluates quantitatively the efficacy of lead molecules for NAFLD/NASH on whole mice liver sections. Biocellvia quantifies on digital scans of liver sections three key parameters involved in Non Alcoholic Steato-Hepatitis (NASH) : steatosis, fibrosis and inflammation. This accuracy enables to evaluate those parameters with high reliability. Biocellvia enables “Big Pharma”, biotechs, CRO and academic research teams to get GO/ NO GO decisions thanks to robust data produced by its own algorithms. Biocellvia’s technology is protected by patent and commercialized as a service. Fully-automated quantitative digital image analysis can replace scoring performed by pathologists as we can read it in the abstract : “Automated measurement of steatosis (macrovesicular steatosis area) revealed a strong correlation with steatosis scores (r = 0.89), micro-CT liver density, liver lipid content (r = 0.89), and gene expression of CD36 (r = 0.87). Automatic assessment of the number of F4/80-immunolabelled crown-like structures strongly correlated with conventional inflammatory scores (r = 0.79). In Foz HF mice, collagen deposition, evident at week 20 and progressing at week 34, was automatically quantified on picrosirius red-stained entire liver sections.”
Link to the article : https://www.nature.com/articles/s41374-019-0315-9